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Verdens helseorganisasjons smertetrapp for kreftrelaterte smerter gjelder smerter som skyldes kreftsykdom og ikke andre smerterVurderingen tager udover risikoen for forgiftning blandt andet også udgangspunkt i "stoffets afhængighedsskabende potentiale" og "risiko for anden sygdom eller skadevirkning som følge af brug af stoffet".Langvarig bruk